Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → Bazedoxifene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Azepane | HCID 8119 | — |
| 반응물 | bazedoxifene 5-Benzyloxy-2(4-benzyloxyphenyl)-1-[4-(2-bromoethoxy)benzyl]-3-methyl-indole | HCID 131734316 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | Bazedoxifene | HCID 154257 | — |
반응 단계
European Patent Application No. 0802183 describes a synthesis of bazedoxifene 5-Benzyloxy-2(4-benzyloxyphenyl)-1-[4-(2-bromoethoxy)benzyl]-3-methyl-indole is reacted with azepan, under suitable reaction conditions, followed by deprotection to yield bazedoxifene, which on subsequent treatment with acetone and acetic acid gives bazedoxifene acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09212172B2 |
| 출처 데이터셋 | uspto-grants-2015_12 |
| ORD ID | ord-30e213a5c70c49b3815a389b696eeaac |
| 출처 메모 | uspto-grants-2015_12 |