Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

HRID 15035

반응식

HRID 15035 반응식
C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][N:29]([C:32]2[CH:37]=[CH:36][C:35]([O:38]C3CCCCO3)=[CH:34][CH:33]=2)[C:28](=[O:45])[CH:27]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][N:29]([C:32]2[CH:33]=[CH:34][C:35]([OH:38])=[CH:36][CH:37]=2)[C:28](=[O:45])[CH:27]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 684306714-benzyloxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one

생성물 1

HCID 684312834-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one수율 98%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Pyridinium p-toluenesulfonate (65 mg) was added to an ethanol solution (16 mL) of 4-benzyloxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one (982 mg, 2.60 mmols) and refluxed for an hour. The reaction liquid was cooled to room temperature and the precipitate was recovered by filtration and washed with water and ethyl acetate to provide the title compound (746 mg, 98%).

후처리

  1. temperaturerefluxed for an hour
  2. customThe reaction liquid
  3. filtrationthe precipitate was recovered by filtration
  4. washwashed with water and ethyl acetate

출처 및 근거

ORD 기록
ord-7d8e8bb1d0ff40a88da8478839fb9b50
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732456B2

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