Tetrahydrofuran → 4-hydroxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one

HRID 15039노트

반응식

HRID 15039 반응식
C1COCC1.C([O:13][C:14]1[CH:19]=[CH:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]3[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)=[CH:22][CH:21]=2)[C:16](=[O:35])[CH:15]=1)C1C=CC=CC=1>[H][H].[Pd]>[OH:13][C:14]1[CH:19]=[CH:18][N:17]([C:20]2[CH:21]=[CH:22][C:23]([O:26][CH2:27][CH2:28][N:29]3[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]3)=[CH:24][CH:25]=2)[C:16](=[O:35])[CH:15]=1

참가 물질

5

반응물 2

HCID 8028TetrahydrofuranHCID 247808834-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one

생성물 1

HCID 684300184-hydroxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one수율 74.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 178418361HCID 178418361, 화합물용매

실험 절차

Into a THF (10 mL) solution of 4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one (Example 2, 130 mg, 0.32 mmol), 10% palladium-on-carbon (165 mg) was added and stirred at room temperature for 10 hours in hydrogen atmosphere. The reaction liquid was filtered, washed thoroughly with methanol, and the filtrate was concentrated under reduced pressure. THF was added to the resulting residue and the formed precipitate was recovered by filtration and dried to provide the title compound (75 mg, 74%).

후처리

  1. customThe reaction liquid
  2. filtrationwas filtered
  3. washwashed thoroughly with methanol
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. additionTHF was added to the resulting residue
  6. filtrationthe formed precipitate was recovered by filtration
  7. customdried

출처 및 근거

ORD 기록
ord-e0491db91f0f4cdfb76c6bf620a3cd51
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732456B2

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