Ammonium Hydroxide → HCID 178453129, 화합물

HRID 1504074노트

반응식

HRID 1504074 반응식
C(=O)(OC(C)(C)C)[O:2][C:3]1[C:4]2[CH:11]=[C:10]([CH2:12][CH2:13][NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[S:9][C:5]=2[N:6]=[CH:7][N:8]=1.[NH4+].[OH-]>CO>[OH:2][C:3]1[C:4]2[CH:11]=[C:10]([CH2:12][CH2:13][NH:14][C:15](=[O:16])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21])[S:9][C:5]=2[N:6]=[CH:7][N:8]=1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 86695233HCID 86695233, 화합물

생성물 1

HCID 178453129HCID 178453129, 화합물수율 91%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a 25-mL round-bottom flask containing a solution of 6-(2-[[(tert-butoxy)carbonyl]amino]ethyl)thieno[2,3-d]pyrimidin-4-yl tert-butyl carbonate (370 mg, 0.94 mmol, 1.00 equiv) in 10 mL of methanol was added NH4OH (2.1 mL) at room temperature and the resulting solution was stirred for 2 hours under N2. After completion, the resulting mixture was concentrated under vacuum and the residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:1) to afford 252 mg (91%) of the desired tert-butyl N-(2-[4-hydroxythieno[2,3-d]pyrimidin-6-yl]ethyl)carbamate as a white solid. MS (ES): m/z 296 (M+H)+.

후처리

  1. concentrationAfter completion, the resulting mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-f7fedced1a7f44b884a3751278175272
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09212190B2

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