Water → Furan-2-acetic acid

HRID 1504297

반응식

HRID 1504297 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]#N.[OH-:9].[K+].[OH2:11]>C(OCC)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([OH:11])=[O:9]

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 109095152-Furanacetonitrile

생성물 1

HCID 75974Furan-2-acetic acid

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

2-(Furan-2-yl)acetonitrile was suspended in 300 mL of distilled water, mixed with 50 g (0.89 mmol) of potassium hydroxide and heated for 4 hours under reflux. After completion of the reaction, the reaction solution was diluted with diethyl ether and separated. The resulting aqueous layer was acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure to give 25.2 g of the desired product.

후처리

  1. temperatureheated for 4 hours
  2. temperatureunder reflux
  3. customAfter completion of the reaction
  4. customseparated
  5. extractionextracted with ethyl acetate
  6. washThe organic layer was washed with saturated aqueous sodium chloride
  7. dry with materialdried over anhydrous magnesium sulfate
  8. filtrationfiltered
  9. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-deaf3f2d8af742a6bf8d4ad1110274b8
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09212348B2

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