HCID 14129197, 화합물 → HCID 86664803, 화합물

HRID 1504317노트

반응식

HRID 1504317 반응식
[Br:1][C:2]1[C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][C:5]([NH2:13])=[C:4]([F:14])[CH:3]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:22](Cl)=[O:23])=[CH:18][N:17]=1>C(Cl)Cl.CC(N(C)C)=O>[Br:1][C:2]1[C:7]([O:8][C:9]([F:11])([F:12])[F:10])=[CH:6][C:5]([NH:13][C:22](=[O:23])[C:19]2[CH:20]=[CH:21][C:16]([F:15])=[N:17][CH:18]=2)=[C:4]([F:14])[CH:3]=1

참가 물질

5

반응물 2

HCID 14129197HCID 14129197, 화합물HCID 146236022-Fluoropyridine-5-carbonyl chloride

생성물 1

HCID 86664803HCID 86664803, 화합물

시약·촉매·용매 2

HCID 31374Dimethylacetamide촉매HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 4-bromo-2-fluoro-5-trifluoromethoxy-phenylamine (500 mg, 2 mmol) dissolved in DCM (1 mL) was slowly added a solution of 2-fluoropyridine-5-carbonyl chloride (290 mg, 1.8 mmol) in DCM (1 mL). A few drops of DMA were added and the reaction mixture was concentrated to form N-(4-bromo-2-fluoro-5-trifluoromethoxy-phenyl)-6-fluoro-nicotinamide as a purple solid.

후처리

  1. concentrationthe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-326ea7eafd36496bb1da16a0e7b9828e
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09212168B2

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