Cesium carbonate → Tert-butyl 3-(5-bromo-4-fluoro-2-(6-(N-(isoxazol-3-yl)-N-(4-methoxybenzyl)sulfamoyl)-2-oxoquinolin-1(2H)-yl)phenoxy)pyrrolidine-1-carboxylate

반응식

I[CH:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1.[Br:14][C:15]1[C:20]([F:21])=[CH:19][C:18]([N:22]2[C:31]3[C:26](=[CH:27][C:28]([S:32]([N:35]([C:45]4[CH:49]=[CH:48][O:47][N:46]=4)[CH2:36][C:37]4[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[CH:39][CH:38]=4)(=[O:34])=[O:33])=[CH:29][CH:30]=3)[CH:25]=[CH:24][C:23]2=[O:50])=[C:17]([OH:51])[CH:16]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[Br:14][C:15]1[C:20]([F:21])=[CH:19][C:18]([N:22]2[C:31]3[C:26](=[CH:27][C:28]([S:32](=[O:33])(=[O:34])[N:35]([C:45]4[CH:49]=[CH:48][O:47][N:46]=4)[CH2:36][C:37]4[CH:38]=[CH:39][C:40]([O:43][CH3:44])=[CH:41][CH:42]=4)=[CH:29][CH:30]=3)[CH:25]=[CH:24][C:23]2=[O:50])=[C:17]([CH:16]=1)[O:51][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1