참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Sodium chlorodifluoroacetate | HCID 2734985 | — |
| 반응물 | 2-Bromo-5-hydroxypyridine | HCID 2762865 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 2-Bromo-5-(difluoromethoxy)pyridine | HCID 23120579 | 43% |
반응 단계
Potassium carbonate (2.4 g, 17.3 mmols) and sodium chlorodifluoroacetate (4.2 g, 27.5 mmols) were added to a DMF (20 mL) solution of 2-bromo-5-hydroxypyridine (2.4 g, 13.8 mmols) and stirred overnight at 80° C. The reaction liquid was cooled to room temperature, added ether, washed with water and dried over anhydrous magnesium sulfate. Concentrating the solvent under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-300; hexane:ethyl acetate=100:1-100:2) to provide the title compound (1.32 g, 43%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07732456B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-a7269e992a824e05b5d1f6a6b677604a |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
