4-Nitrophenyl chloroformate → HCID 86730055, 화합물

HRID 1504596노트

반응식

HRID 1504596 반응식
[OH:1][CH:2]1[CH2:5][N:4]([C:6]2[CH:14]=[CH:13][C:9]([C:10]([NH2:12])=[O:11])=[CH:8][N:7]=2)[CH2:3]1.[C:15](Cl)(=[O:26])[O:16][C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=1>C(Cl)Cl>[C:15](=[O:26])([O:16][C:17]1[CH:18]=[CH:19][C:20]([N+:23]([O-:25])=[O:24])=[CH:21][CH:22]=1)[O:1][CH:2]1[CH2:5][N:4]([C:6]2[CH:14]=[CH:13][C:9]([C:10](=[O:11])[NH2:12])=[CH:8][N:7]=2)[CH2:3]1

참가 물질

4

반응물 2

HCID 821294-Nitrophenyl chloroformateHCID 78992995HCID 78992995, 화합물

생성물 1

HCID 86730055HCID 86730055, 화합물수율 10%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 6-(3-hydroxyazetidin-1-yl)nicotinamide (0.19 g, 1 mmol) in DCM (5 mL) under nitrogen was added 4-nitrophenyl carbonochloridate (0.20 g, 1 mmol). The resulting solution was stirred under N2 at room temperature for 24 h. The reaction mixture was then filtered and the filter cake was washed with DCM. The combined filtrates were concentrated to afford the title compound (36 mg, 10%) as a yellow liquid. [LCMS RtA=1.71 min, [M+H]+=359.0].

후처리

  1. filtrationThe reaction mixture was then filtered
  2. washthe filter cake was washed with DCM
  3. concentrationThe combined filtrates were concentrated

출처 및 근거

ORD 기록
ord-df339d41ae98444dae31b6274123f3ed
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216182B2

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