4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine → 6-(4-Aminopiperidin-1-yl)nicotinamide hydrochloride

반응식

[ClH:1].CCOC(C)=O.[C:8]([C:11]1[CH:12]=[CH:13][C:14]([N:17]2[CH2:22][CH2:21][CH:20]([NH:23]C(=O)OC(C)(C)C)[CH2:19][CH2:18]2)=[N:15][CH:16]=1)(=[O:10])[NH2:9]>>[ClH:1].[NH2:23][CH:20]1[CH2:19][CH2:18][N:17]([C:14]2[CH:13]=[CH:12][C:11]([C:8]([NH2:9])=[O:10])=[CH:16][N:15]=2)[CH2:22][CH2:21]1

참가 물질

반응물 2

HCID 114840424-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine

HCID 21866389Hydrogen chloride-ethyl acetate

생성물 1

HCID 693590386-(4-Aminopiperidin-1-yl)nicotinamide hydrochloride수율 94%

실험 절차

To a stirred solution of HCl/EtOAc (9 ml, 3N) was added tert-butyl 1-(5-carbamoylpyridin-2-yl)piperidin-4-ylcarbamate (400 mg) and the mixture was stirred at room temperature for 4 h. The solid was collected by filtration and washed with EtOAc to give a white solid (300 mg, 94%). [LCMS RtA=0.85 min, [M+H]+=221.1].

후처리

filtrationThe solid was collected by filtration
washwashed with EtOAc

출처 및 근거

ORD 기록: ord-ba454e5f155b49ab89d268765bc670e2
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09216182B2

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