Potassium Carbonate → 5-(3-Hydroxypyrrolidin-1-yl)picolinonitrile
반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1.Cl.[NH:11]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[OH:16][CH:13]1[CH2:14][CH2:15][N:11]([C:2]2[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=2)[CH2:12]1참가 물질
5
실험 절차
A mixture of 5-chloropicolinonitrile (2 g, 14.4 mmol), pyrrolidin-3-ol hydrochloride (2 g, 25.9 mmol) and K2CO3 (4 g, 28.9 mmol) in DMF (15 mL) was stirred at 140□ for 16 h. The organic solvent was removed under vacuum and the residue was taken into DCM (200 mL). Solid was removed by filtration and the filtrate was concentrated to give crude product (2.0 g yield 73%) as a yellow solid. [LCMS: RtA=1.19 min, m/z 190.2 [M+H]+].
후처리
- customThe organic solvent was removed under vacuum
- customSolid was removed by filtration
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-6aef93b6768d4374969efb501e788bcd
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09216182B2
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