Dichloromethane → 4,5-dibromo-2-(4-hydroxyphenyl)-2H-pyridazin-3-one
반응식
ClCCl.B(Br)(Br)Br.[Br:8][C:9]1[C:10](=[O:24])[N:11]([C:16]2[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=2)[N:12]=[CH:13][C:14]=1[Br:15]>O>[Br:8][C:9]1[C:10](=[O:24])[N:11]([C:16]2[CH:17]=[CH:18][C:19]([OH:22])=[CH:20][CH:21]=2)[N:12]=[CH:13][C:14]=1[Br:15]참가 물질
5
실험 절차
A 1N dichloromethane solution (5.5 mL) of boron tribromide was added to a dichloromethane solution (30 mL) of 4,5-dibromo-2-(4-methoxyphenyl)-2H-pyridazin-3-one (1.1 g, 3.06 mmols), and stirred overnight at room temperature. Water (30 mL) was added and stirred for 30 minutes. The resulting precipitate was recovered by filtration, washed with water and chloroform and dried to provide the title compound (1.03 g, 97%).
후처리
- stirringstirred for 30 minutes
- filtrationThe resulting precipitate was recovered by filtration
- washwashed with water and chloroform
- customdried
출처 및 근거
- ORD 기록
- ord-3d9d0cf7ddde471781a2540f0cc9ffef
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07732456B2
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