Cesium carbonate → 5-{[(1R,2S)-2-amino cyclohexyl]amino}-3-[(6-ethylpyridin-2-yl)amino]pyridine-2-carbonitrile

반응식

OC(C(F)(F)F)=O.[NH2:8][C@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[NH:15][C:16]1[CH:17]=[C:18](Br)[C:19]([C:22]#[N:23])=[N:20][CH:21]=1.[NH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH2:32][CH3:33])[N:27]=1.CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.C(=O)([O-])[O-].[Cs+].[Cs+]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[NH2:8][C@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[NH:15][C:16]1[CH:17]=[C:18]([NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([CH2:32][CH3:33])[N:27]=2)[C:19]([C:22]#[N:23])=[N:20][CH:21]=1