Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanoacetamide → 5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanoacetamide | HCID 7898 | — |
| 반응물 | Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl ester | HCID 613145 | — |
| 반응물 | 2-(4-Chlorophenyl)-3-(dimethylamino)acrylaldehyde | HCID 3448972 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 2763910 | — |
반응 단계
To solution of sodium methoxide (7.52 g) in methanol (130 ml) was added cyanoacetamide (5.84 g) followed by 2-(4-chlorophenyl)-3-dimethylaminopropenal and the resulting suspension was refluxed overnight. During this time a yellow solid was formed. The mixture was cooled to room temperature and glacial acetic add (50 ml) was added followed by water (100 ml). The resulting yellow orange solid was filtered off, washed several times with water and dried to yield 8.1 g of 3-cyano-5-(4-chlorophenyl)-2-pyridinone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726162 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-119328d4f6c144a381d29ff2f0cd48ad |
| 출처 메모 | uspto-grants-1998_03 |