(7-Bromo-benzo[1,2,5]thiadiazol-4-yl)-methanol → 7-Bromo-2,1,3-benzothiadiazole-4-carboxaldehyde

HRID 1505242노트

반응식

HRID 1505242 반응식
[Br:1][C:2]1[C:10]2[C:6](=[N:7][S:8][N:9]=2)[C:5]([CH2:11][OH:12])=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+4].[O-2]>[Br:1][C:2]1[C:10]2[C:6](=[N:7][S:8][N:9]=2)[C:5]([CH:11]=[O:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 58497958(7-Bromo-benzo[1,2,5]thiadiazol-4-yl)-methanol

생성물 1

HCID 584979627-Bromo-2,1,3-benzothiadiazole-4-carboxaldehyde수율 83%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of (7-bromo-benzo[1,2,5]thiadiazol-4-yl)-methanol (Example 5.2) (20.22 g) in dichloromethane (185 ml) was added manganese(IV) oxide (71.7 g). The suspension was stirred at ambient temperature for 16 hours. The reaction mixture was filtered through a plug of Celite®. The filtrate was concentrated to give 7-bromo-benzo[1,2,5]thiadiazole-4-carbaldehyde (16.65 g) as an orange solid. 1H-NMR (400 MHz, CDCl3): 10.74 (s, 1H), 8.11-8.05 (m, 2H) ppm.

후처리

  1. filtrationThe reaction mixture was filtered through a plug of Celite®
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-3b53fb16fb384addbdd88e5d3602d48d
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216973B2

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