(7-Bromo-2-methyl-benzo[d]oxazol-4-yl)methanol → 7-Bromo-2-methyl-benzo[d]oxazole-4-carbaldehyde
반응식
[Br:1][C:2]1[C:10]2[O:9][C:8]([CH3:11])=[N:7][C:6]=2[C:5]([CH2:12][OH:13])=[CH:4][CH:3]=1>ClCCl.[O-2].[Mn+4].[O-2]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]=[O:13])=[C:6]2[C:10]=1[O:9][C:8]([CH3:11])=[N:7]2참가 물질
4
실험 절차
To a solution of (7-bromo-2-methyl-benzo[d]oxazol-4-yl)methanol (Example 6.5) (5.16 g) in dichloromethane (300 ml) was added manganese(IV) oxide (59.9 g) and the suspension stirred at ambient temperature for 16 hours. The reaction mixture was filtered through a plug of silica gel and the filtrate concentrated to give 7-bromo-2-methyl-benzo[d]oxazole-4-carbaldehyde (3.23 g). LC-MS: RT=1.83 min, [M+H]+=240.0/242.0, method A.
후처리
- filtrationThe reaction mixture was filtered through a plug of silica gel
- concentrationthe filtrate concentrated
출처 및 근거
- ORD 기록
- ord-8a24ab132e7249478c20f756f49b9915
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09216973B2
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