4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-(4-hydroxyphenyl)-1H-pyridin-2-one → 4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one
반응식
C(OC1[CH:14]=[CH:13][N:12]([C:15]2[CH:20]=[CH:19][C:18](O)=CC=2)C(=O)C=1)C1C=CC=CC=1.[CH3:23][C:24]([O:27][C:28]1[CH:33]=[CH:32][C:31](/[CH:34]=[CH:35]/[C:36]2[CH:41]=[CH:40][N:39]([C:42]3[CH:47]=[CH:46][C:45]([OH:48])=[CH:44][CH:43]=3)[C:38](=[O:49])[CH:37]=2)=[CH:30][CH:29]=1)([CH3:26])[CH3:25]>>[CH3:26][C:24]([O:27][C:28]1[CH:29]=[CH:30][C:31](/[CH:34]=[CH:35]/[C:36]2[CH:41]=[CH:40][N:39]([C:42]3[CH:43]=[CH:44][C:45]([O:48][CH2:14][CH2:13][N:12]4[CH2:15][CH2:20][CH2:19][CH2:18]4)=[CH:46][CH:47]=3)[C:38](=[O:49])[CH:37]=2)=[CH:32][CH:33]=1)([CH3:23])[CH3:25]참가 물질
3
실험 절차
Step (3) of Example 12 was repeated except that 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one was replaced with 4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-(4-hydroxyphenyl)-1H-pyridin-2-one, to provide the title compound.
출처 및 근거
- ORD 기록
- ord-d1c244cae05843078c2731495c3f27ca