Water → 4-(3-Methoxy-4-methylphenoxy)aniline

HRID 1505316노트

반응식

HRID 1505316 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)=[CH:4][C:3]=1[O:18][CH3:19].O.[Cl-].[NH4+]>O1CCCC1>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)=[CH:4][C:3]=1[O:18][CH3:19]

참가 물질

5

반응물 3

HCID 962WaterHCID 25517Ammonium ChlorideHCID 672363822-Methoxy-1-methyl-4-(4-nitrophenoxy)benzene2회

생성물 1

HCID 672355644-(3-Methoxy-4-methylphenoxy)aniline

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-methyl-2-(methyloxy)-4-[(4-nitrophenyl)oxy]benzene (Intermediate 19, 1.43 g) in tetrahydrofuran (65 mL)/water (32.5 mL) iron (1.540 g, 27.6 mmol) and then ammonium chloride (1.475 g, 27.6 mmol) were added and the reaction mixture was stirred for 5 hours at room temperature. The catalyst was filtered off and the solution was diluted with a saturated solution of Na2CO3 (10 mL) and extracted with ethyl acetate (2 times 60 mL). Combined organic layers were dried over sodium sulphate, filtered and evaporated to the title compound (1.25 g) as a brown/red solid.

후처리

  1. filtrationThe catalyst was filtered off
  2. additionthe solution was diluted with a saturated solution of Na2CO3 (10 mL)
  3. extractionextracted with ethyl acetate (2 times 60 mL)
  4. dry with materialCombined organic layers were dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated to the title compound (1.25 g) as a brown/red solid

출처 및 근거

ORD 기록
ord-5bfc12b90ce54a438f0fdd5a44317135
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216967B2

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