Dichloromethane → HCID 67235119, 화합물

HRID 1505318노트

반응식

HRID 1505318 반응식
[CH3:1][C@@H:2]([NH:22]C(=O)OC(C)(C)C)[C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([O:20][CH3:21])[CH:14]=2)=[CH:8][CH:7]=1)=[O:4].ClCCl>>[CH3:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][C:9]2[CH:10]=[CH:11][C:6]([NH:5][C:3](=[O:4])[C@@H:2]([CH3:1])[NH2:22])=[CH:7][CH:8]=2)=[CH:14][C:15]=1[O:20][CH3:21]

참가 물질

3

반응물 2

HCID 6344DichloromethaneHCID 68322429HCID 68322429, 화합물2회

생성물 1

HCID 67235119HCID 67235119, 화합물수율 97.3%

실험 절차

To a solution of 1,1-dimethylethyl {(1R)-1-methyl-2-[(4-{[4-methyl-3-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate (Intermediate 21, 300 mg) in dry dichloromethane (7.5 mL) TFA (2.5 mL, 32.4 mmol) was slowly added and the reaction mixture was stirred for 1.5 hours at room temperature. The solvent and the excess of TFA were evaporated and the residue was purified by SCX cartridge (10 g) to afford the title compound as an orange oil (219 mg).

후처리

  1. customThe solvent and the excess of TFA were evaporated
  2. customthe residue was purified by SCX cartridge (10 g)

출처 및 근거

ORD 기록
ord-5fc28f03edb34c5c944f156534275047
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216967B2

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