HCID 67235239, 화합물 → HCID 67235719, 화합물

HRID 1505324노트

반응식

HRID 1505324 반응식
[CH3:1][CH:2]([O:4][C:5]1[CH:6]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][N:13]=2)[CH:8]=[CH:9][CH:10]=1)[CH3:3]>CO.[Pd]>[CH3:3][CH:2]([O:4][C:5]1[CH:6]=[C:7]([O:11][C:12]2[N:13]=[CH:14][C:15]([NH2:18])=[CH:16][CH:17]=2)[CH:8]=[CH:9][CH:10]=1)[CH3:1]

참가 물질

4

반응물 1

HCID 67235239HCID 67235239, 화합물2회

생성물 1

HCID 67235719HCID 67235719, 화합물수율 93.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 2-({3-[(1-methylethyl)oxy]phenyl}oxy)-5-nitropyridine (Intermediate 28, 670 mg, 2.45 mmol) in methanol (50 mL) was added Pd/C (10%, 100 mg, 0.1 wet. e.g.) and the flask was filled in with H2. The resulting mixture was stirred at room temperature under H2 atmosphere overnight and filtered. The filtrate was concentrated under vacuum to afford the title compound as a brown solid (560 mg).

후처리

  1. additionthe flask was filled in with H2
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-9fab902458bc4fceb25c2ef4fc03254a
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216967B2

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