Trifluoroacetic acid → 4-[(E)-2-(4-hydroxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}-1H-pyridin-2-one

HRID 15054노트

반응식

HRID 15054 반응식
FC(F)(F)C(O)=O.CC([O:12][C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]2[CH:26]=[CH:25][N:24]([C:27]3[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH2:35][N:36]4[CH2:40][CH2:39][CH2:38][CH2:37]4)=[CH:29][CH:28]=3)[C:23](=[O:41])[CH:22]=2)=[CH:15][CH:14]=1)(C)C>>[OH:12][C:13]1[CH:18]=[CH:17][C:16](/[CH:19]=[CH:20]/[C:21]2[CH:26]=[CH:25][N:24]([C:27]3[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH2:35][N:36]4[CH2:37][CH2:38][CH2:39][CH2:40]4)=[CH:29][CH:28]=3)[C:23](=[O:41])[CH:22]=2)=[CH:15][CH:14]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 684300224-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

생성물 1

HCID 684306454-[(E)-2-(4-hydroxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}-1H-pyridin-2-one수율 92.7%

실험 절차

Trifluoroacetic acid (2 mL) was added to 4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one (120 mg, 0.26 mmol) and stirred at room temperature for 30 minutes. After concentrating the reaction liquid under reduced pressure, chloroform was added to the reaction liquid which then was washed with aqueous sodium hydrogencarbonate solution and dried over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the title compound (97 mg, 92%) was obtained as a white solid.

후처리

  1. concentrationAfter concentrating
  2. customthe reaction liquid under reduced pressure, chloroform
  3. additionwas added to the reaction liquid which
  4. washthen was washed with aqueous sodium hydrogencarbonate solution
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationConcentrating the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-241179f0589349129fa9c34052951db9
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732456B2

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