Potassium Carbonate → HCID 90229320, 화합물
반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(=O)([O-])[O-].[K+].[K+].I[CH2:20][CH:21]([F:23])[F:22]>CC(C)=O>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH2:20][CH:21]([F:23])[F:22])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]참가 물질
5
실험 절차
To a suspension of methyl 2-chloro-5-hydroxybenzoate (50 mg) and potassium carbonate (111 mg) in acetone (1 mL) was added 2-iodo-1,1-difluoroethane (35 μL), and the suspension was reacted at 120° C. for 10 minutes in a microwave synthesizer (Biotage, Initiator). After reaction at 130° C. for additional 15 minutes, the reaction mixture was directly purified on silica gel column chromatography to obtain the titled compound (55 mg) as yellow oil.
후처리
- customthe suspension was reacted at 120° C. for 10 minutes in a microwave synthesizer (Biotage, Initiator)
- customAfter reaction at 130° C. for additional 15 minutes
- customthe reaction mixture was directly purified on silica gel column chromatography
출처 및 근거
- ORD 기록
- ord-5e3bed580f5946c9a5757d95a2858363
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09216968B2
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