Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3-Diaminobenzoic acid methyl ester → Methyl 2-(2-ethoxy-2-oxoethyl)-1H-benzimidazole-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3-Diaminobenzoic acid methyl ester | HCID 571825 | — |
| 반응물 | Ethyl beta-amino-beta-ethoxyacrylate hydrochloride | HCID 53395434 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Methyl 2-(2-ethoxy-2-oxoethyl)-1H-benzimidazole-4-carboxylate | HCID 90229347 | 106.2% |
반응 단계
A solution of methyl 2,3-diaminobenzoate (680 mg) and ethyl 3-amino-3-ethoxyacrylate hydrochloride (880 mg) in EtOH (12 mL) was stirred at 60° C. for 2 hours. EtOH was removed under reduced pressure, and the residue was purified on column chromatography to obtain the titled compound (1.14 g) as a pale yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09216968B2 |
| 출처 데이터셋 | uspto-grants-2015_12 |
| ORD ID | ord-1b90bd2e121847489527c70af599b16e |
| 출처 메모 | uspto-grants-2015_12 |