Methanesulfonyl chloride → HCID 178477812, 화합물
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[N:11]=[CH:10][NH:9][C:5]2=[N+:6]([O-])[CH:7]=1.CS([Cl:16])(=O)=O.C(=O)([O-])O.[Na+]>CN(C)C=O>[Br:1][C:2]1[C:3]([Cl:16])=[C:4]2[N:11]=[CH:10][NH:9][C:5]2=[N:6][CH:7]=1참가 물질
5
반응 조건
- 온도
- 73 °C
실험 절차
6-Bromo-3H-imidazo[4,5-b]pyridine 4-oxide (1.88 g, 8.82 mmol) in N,N-dimethylformamide (12 mL) was heated to 50° C., mixed with methansulfonyl chloride (8.00 mL, 103 mmol) and stirred at 73° C. for 3 hours. The reaction mixture was cooled with ice and gradually poured into saturated aqueous sodium hydrogen carbonate (75 mL), and the precipitated solid was collected by filtration, washed with water and chloroform and dried under reduced pressure to give the title compound as a dark brown solid (1.07 g, yield 52%).
후처리
- temperatureThe reaction mixture was cooled with ice
- filtrationthe precipitated solid was collected by filtration
- washwashed with water and chloroform
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-99b09c1769904fb2808fc4a13284a878
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09216999B2
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