Water → Phenyl 1,3,4-thiadiazol-2-ylcarbamate
반응식
[S:1]1[CH:5]=[N:4][N:3]=[C:2]1[NH2:6].Cl[C:8]([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:9].O>CN(C)C(=O)C>[S:1]1[CH:5]=[N:4][N:3]=[C:2]1[NH:6][C:8](=[O:9])[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1참가 물질
5
실험 절차
1,3,4-Thiadiazol-2-amine (253 mg, 2.50 mmol) in N,N-dimethylacetamide (3 mL) was stirred with phenyl chloroformate (392 μL, 3.13 mmol) at room temperature for one day. Water was added to the reaction mixture, and the precipitated solid was collected by filtration, washed with water and hexane and dried under reduced pressure to give the title compound as a colorless solid (418 mg, yield 76%).
후처리
- filtrationthe precipitated solid was collected by filtration
- washwashed with water and hexane
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-b8f2225237f1486bb3750b413c9bb529
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09216999B2
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