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Chloroform methanol → 1-(Piperidin-4-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-h][1,6]naphthyridin-4(7H)-one

HRID 1506241
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HRID 1506241 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:23]3[C:18](=[CH:19][N:20]=[C:21]4[N:26]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[CH:25]=[CH:24][C:22]4=3)[C:17](=[O:35])[CH:16]=[CH:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.C(Cl)(Cl)Cl.CO>CO.[C].[Pd]>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:23]3[C:18](=[CH:19][N:20]=[C:21]4[N:26]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:33])([CH3:32])[CH3:34])[CH:25]=[CH:24][C:22]4=3)[C:17](=[O:35])[CH:16]=[CH:15]2)[CH2:10][CH2:9]1
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참가 물질

5

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HCID 21584188Chloroform methanolHCID 712584011-(1-Benzylpiperidin-4-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-h][1,6]naphthyridin-4(7H)-one

생성물 1

HCID 712582261-(Piperidin-4-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-h][1,6]naphthyridin-4(7H)-one수율 68%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매
HCID 887
Methanol
용매

실험 절차

1-(1-Benzylpiperidin-4-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-h][1,6]naphthyridin-4(7H)-one (341 mg, 0.697 mmol) in methanol was stirred with 5% palladium-carbon (500 mg) for one day under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (Hi Flash column amino type manufactured by Yamazen Corporation: chloroform/methanol=9/1/(v/v)) to give the title compound (189 mg, yield 68%).

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (Hi Flash column amino type

출처 및 근거

ORD 기록
ord-c4cbe7a83e944ed7a71c2714694b47f5
출처 데이터셋
uspto-grants-2015_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09216999B2

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