Triethylamine → 7-(2,2-Dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(5-phenyl-4-(trifluoromethyl)-isoxazol-3-yl)-3a,4,5,9b-tetrahydroisoxazolo[5,4-f]quinoline

HRID 1506413노트

반응식

HRID 1506413 반응식
[CH3:1][C:2]1([CH3:23])[O:6][CH:5]([C:7]2[CH:16]=[CH:15][C:14]3[C:13]([N:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)=[CH:12][CH2:11][CH2:10][C:9]=3[N:8]=2)[CH2:4][O:3]1.[OH:24]/[N:25]=[C:26](\Cl)/[C:27]1[C:31]([C:32]([F:35])([F:34])[F:33])=[C:30]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[O:29][N:28]=1.C(N(CC)CC)C>ClCCl>[CH3:1][C:2]1([CH3:23])[O:6][CH:5]([C:7]2[CH:16]=[CH:15][C:14]3[C:13]4([N:17]5[CH2:22][CH2:21][O:20][CH2:19][CH2:18]5)[O:24][N:25]=[C:26]([C:27]5[C:31]([C:32]([F:35])([F:33])[F:34])=[C:30]([C:36]6[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=6)[O:29][N:28]=5)[CH:12]4[CH2:11][CH2:10][C:9]=3[N:8]=2)[CH2:4][O:3]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 671700704-(2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-7,8-dihydroquinolin-5-yl)morpholineHCID 136374584(3Z)-N-hydroxy-5-phenyl-4-(trifluoromethyl)-1,2-oxazole-3-carboximidoyl chloride2회

생성물 1

HCID 671705577-(2,2-Dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(5-phenyl-4-(trifluoromethyl)-isoxazol-3-yl)-3a,4,5,9b-tetrahydroisoxazolo[5,4-f]quinoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

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온도
0 °C

실험 절차

To a solution of 4-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)-7,8-dihydroquinolin-5-yl)morpholine (Preparation 15F, 0.194 g, 0.613 mmol) in dichloromethane (2 mL) was added a solution of (Z)—N-hydroxy-5-phenyl-4-(trifluoromethyl)isoxazole-3-carbimidoyl chloride (Intermediate 13, 0.210 g, 0.613 mmol) in dichloromethane (1 mL). The reaction mixture was cooled to 0° C., and triethylamine (0.093 mL, 0.674 mmol) was added dropwise over 2 min. The ice-bath was removed, and the resulting cloudy solution was stirred at room temperature for 30 min. The reaction mixture was diluted with dichloromethane (30 mL), washed with water (15 mL), dried over anhydrous sodium sulfate, and concentrated to give the morpholino-intermediate, 7-(2,2-dimethyl-1,3-dioxolan-4-yl)-9b-morpholino-3-(5-phenyl-4-(trifluoromethyl)-isoxazol-3-yl)-3a,4,5,9b-tetrahydroisoxazolo[5,4-f]quinoline, as an orange oil. To the oil was added dichloroethane (3 mL) and TFA (0.071 mL, 0.920 mmol), and the reaction mixture was heated at 80° C. for 60 min. The reaction mixture was stirred overnight at room temperature. Additional TFA (0.071 mL, 0.920 mmol) was added, and the reaction mixture was heated at 80° C. for 6 h. The reaction mixture was diluted with dichloromethane (30 mL), washed with a saturated aqueous solution of sodium bicarbonate (15 mL), and dried over anhydrous sodium sulfate. Concentration under reduced pressure followed by trituration with methanol with sonication afforded 44 mg of a 3:7 mixture of 1-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydroisoxazolo[5,4-f]quinolin-7-yl)ethane-1,2-diol and 7-(oxiran-2-yl)-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydroisoxazolo[5,4-f]quinoline as a light brown solid.

후처리

  1. customThe ice-bath was removed
  2. additionThe reaction mixture was diluted with dichloromethane (30 mL)
  3. washwashed with water (15 mL)
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7863a567add041ce98f097cebc481bd5
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216972B2

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