Ammonia chloride → 1-(5-methyl-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)-2-phenylethanone

HRID 1506630노트

반응식

HRID 1506630 반응식
[CH3:1][C:2]1[N:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[C:4]([C:7]([O:9]CC)=O)=[N:5][N:6]=1.[CH2:19]([Mg]Cl)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[Cl-].N>C1(C)C=CC=CC=1>[CH3:1][C:2]1[N:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[C:4]([C:7](=[O:9])[CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:5][N:6]=1

참가 물질

5

반응물 3

HCID 20976574Ammonia chlorideHCID 90281310ethyl 5-methyl-4-(o-tolyl)-4H-1,2,4-triazole-3-carboxylateHCID 178418336HCID 178418336, 화합물

생성물 1

HCID 902812771-(5-methyl-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)-2-phenylethanone

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 10C (1.0 g, 4.1 mmol) in toluene cooled by an ice bath, benzylmagnesium chloride (2M in THF) (3.0 mL, 6.0 mmol) was added dropwise. After one hour, ammonia chloride solution was added to the mixture and extracted with ethyl acetate (50 mL twice). The organic layer was dried with Na2SO4, filtered and concentrated and used without further purification. MS (m/z) 292 [M+H]+.

후처리

  1. extractionextracted with ethyl acetate (50 mL twice)
  2. dry with materialThe organic layer was dried with Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customused without further purification

출처 및 근거

ORD 기록
ord-117dee3e4ab740fe9abba715ad453a5d
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09220710B2

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