2-(5-Trifluoromethyl-1H-indol-3-YL)acetic acid → (S)-N-(1-(4-(4-chlorophenyl)isoxazol-3-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-hydroxy-1H-indol-3-yl)acetamide

반응식

ClC1C=CC(C2[O:9]C(C(NC(=O)CC3C4C(=CC=C(F)C=4)NC=3)CC3C=C(F)C=C(F)C=3)=CN=2)=CC=1.FC(F)(F)[C:39]1[CH:40]=[C:41]2[C:45](=[CH:46][CH:47]=1)[NH:44][CH:43]=[C:42]2[CH2:48][C:49]([OH:51])=O.[Cl:54][C:55]1[CH:60]=[CH:59][C:58]([C:61]2[C:62]([C@@H:66]([NH2:76])[CH2:67][C:68]3[CH:73]=[C:72]([F:74])[CH:71]=[C:70]([F:75])[CH:69]=3)=[N:63][O:64][CH:65]=2)=[CH:57][CH:56]=1.Cl.ClC1C=CC(C2OC(C(N)CC3C=C(F)C=C(F)C=3)=CN=2)=CC=1>>[Cl:54][C:55]1[CH:60]=[CH:59][C:58]([C:61]2[C:62]([C@@H:66]([NH:76][C:49](=[O:51])[CH2:48][C:42]3[C:41]4[C:45](=[CH:46][CH:47]=[C:39]([OH:9])[CH:40]=4)[NH:44][CH:43]=3)[CH2:67][C:68]3[CH:73]=[C:72]([F:74])[CH:71]=[C:70]([F:75])[CH:69]=3)=[N:63][O:64][CH:65]=2)=[CH:57][CH:56]=1