2-(5-Trifluoromethyl-1H-indol-3-YL)acetic acid → (R)-N-(1-(4-(4-chlorophenyl)isoxazol-3-yl)-2-(3,5-difluorophenyl)ethyl)-2-(5-hydroxy-1H-indol-3-yl)acetamide

반응식

FC1C=C(C[C@H](NC(=O)CN2C3CCCCC=3C(C(F)(F)F)=N2)C2N(C3C=CC([O:22]C)=CC=3)C=CN=2)C=C(F)C=1.FC(F)(F)[C:43]1[CH:44]=[C:45]2[C:49](=[CH:50][CH:51]=1)[NH:48][CH:47]=[C:46]2[CH2:52][C:53]([OH:55])=O.[Cl:58][C:59]1[CH:64]=[CH:63][C:62]([C:65]2[C:66]([C@H:70]([NH2:80])[CH2:71][C:72]3[CH:77]=[C:76]([F:78])[CH:75]=[C:74]([F:79])[CH:73]=3)=[N:67][O:68][CH:69]=2)=[CH:61][CH:60]=1.FC1C=C(C[C@@H](C2N(C3C=CC(OC)=CC=3)C=CN=2)N)C=C(F)C=1>>[Cl:58][C:59]1[CH:64]=[CH:63][C:62]([C:65]2[C:66]([C@H:70]([NH:80][C:53](=[O:55])[CH2:52][C:46]3[C:45]4[C:49](=[CH:50][CH:51]=[C:43]([OH:22])[CH:44]=4)[NH:48][CH:47]=3)[CH2:71][C:72]3[CH:77]=[C:76]([F:78])[CH:75]=[C:74]([F:79])[CH:73]=3)=[N:67][O:68][CH:69]=2)=[CH:61][CH:60]=1