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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1506774생성일: 2026년 10월 26일

1-Aza-6,9-dichloro-2-methoxyacridine → 7-Chloro-2-methoxy-N-(2-(4-methylpiperazin-1-yl)ethyl)benzo[b][1,5]naphthyridin-10-amine

https://huagongshe.com/reaction/1506774

반응식

참여 물질

역할이름HCID투입량
반응물1-Aza-6,9-dichloro-2-methoxyacridineHCID 23107—
반응물4-Methylpiperazine-1-ethylamineHCID 70284—
생성물7-Chloro-2-methoxy-N-(2-(4-methylpiperazin-1-yl)ethyl)benzo[b][1,5]naphthyridin-10-amineHCID 71006631—

반응 단계

Following the general procedure of Example 1 and making non-critical variations but using 7,10-dichloro-2-methoxypyrido[3,2-b]quinoline and 2-(4-methylpiperazin-1-yl)ethanamine, the title compound was obtained; MS (Found M+1=386). 1H NMR (DMSO-d6, 400 Hz): 8.43-8.41 (d, 1H, J=9.2 Hz), 8.12-8.10 (d, 1H, J=9.2 Hz), 7.87 (b, 1H), 7.2 (s, 1H), 7.2.9-7.27 (d, 1H, J=9.2 Hz) 7.25-7.24 (d, 1H, J=9.2 Hz), 4.10 (m, 2H), 4.06 (s, 3H), 2.70-2.68 (m, 2H), 2.33 (b, 8H), 2.14 (s, 3H).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09221760B2
출처 데이터셋uspto-grants-2015_12
ORD IDord-06680b69475d4b2ba4696a09cbd34eba
출처 메모uspto-grants-2015_12