2-(2-Benzoxazolyl)phenol → HCID 67072674, 화합물

HRID 1506817

반응식

HRID 1506817 반응식
C1(B([O:14][B:15]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)C2C=CC=CC=2)C=CC=CC=1.O[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]1[O:36][C:37]2[CH:43]=[CH:42][CH:41]=[CH:40][C:38]=2[N:39]=1>O1CCCC1>[C:22]1([B:15]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[O:14][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:35]2[O:36][C:37]3[CH:43]=[CH:42][CH:41]=[CH:40][C:38]=3[N:39]=2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

참가 물질

4

반응물 2

HCID 132692-(2-Benzoxazolyl)phenolHCID 596810Diphenylborinic anhydride

생성물 1

HCID 67072674HCID 67072674, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of diphenylborinic anhydride (5.0 g; 0.014 mole) in tetrahydrofuran (20 ml) was added to a solution of 2-(2′-hydroxyphenyl)benzoxazole (3.1 g; 0.014 mole) in tetrahydrofuran (10 ml). The reaction mixture was refluxed under nitrogen for 2 h and allowed to cool to room temperature, then kept in the refrigerator for 18 h. The product was filtered off under suction, washed with methanol and dried under vacuum at 80° C. for 6 h. Yield 4.4 g (84%). The product was further purified by sublimation (85%). M.p 195° C. (DSC, onset); Tg 59° C. Elemental analysis:

후처리

  1. temperatureThe reaction mixture was refluxed under nitrogen for 2 h
  2. filtrationThe product was filtered off under suction
  3. washwashed with methanol
  4. customdried under vacuum at 80° C. for 6 h
  5. customThe product was further purified by sublimation (85%)
  6. customM.p 195° C. (DSC, onset)

출처 및 근거

ORD 기록
ord-0c15ac0549a74bb9b8ae73caa55a46a3
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221770B2

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