Water → 2-(2,6-Difluoro-4-nitrophenyl)propanoic acid

HRID 1506879노트

반응식

HRID 1506879 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[C:4]([F:11])[C:3]=1[C:12](C)([C:18](OCC)=O)[C:13]([O:15]CC)=[O:14].S(=O)(=O)(O)O.O>C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[C:4]([F:11])[C:3]=1[CH:12]([CH3:18])[C:13]([OH:15])=[O:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 58280423HCID 58280423, 화합물

생성물 1

HCID 534295682-(2,6-Difluoro-4-nitrophenyl)propanoic acid수율 85.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of compound (26b) (7.8 g, 24.9 mmol) in acetic acid (28 mL), and concentrated sulfuric acid (8.0 mL), and water (20 mL) were treated in the same manner as in (b) in Production Example 1 to give 4.9 g (85%) of compound (27b) as yellow solid.

출처 및 근거

ORD 기록
ord-97e23ef791194846ab73cdd4db5bd356
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221786B2

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