Potassium Iodide → 1-(3-Hydroxypropyl)-1,2,3-triazole
반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[N:2]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Br[CH2:15][CH2:16][CH2:17][OH:18]>O1CCOCC1>[N:1]1([CH2:15][CH2:16][CH2:17][OH:18])[CH:5]=[CH:4][N:3]=[N:2]1참가 물질
6
반응 조건
- 온도
- 100 °C
실험 절차
1,2,3-triazole (2 g, 28.96 mmol) was dissolved in 1,4-dioxane (40 mL), and potassium carbonate (8 g, 57.92 mmol), potassium iodide (962 mg, 5.79 mmol) and 3-bromopropanol (3.3 mL, 43.43 mmol) were added thereto, followed by stirring at 100° C. for 3 hours. After the reaction was completed, the reactants were cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure. The resulting residue was purified by column chromatography to afford the title compound (2.5 g, 68%).
후처리
- temperaturethe reactants were cooled to room temperature
- filtrationfiltered
- concentrationThe filtrate was concentrated under reduced pressure
- customThe resulting residue was purified by column chromatography
출처 및 근거
- ORD 기록
- ord-f53fdde1f1b443b6830e572b0b326059
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09221790B2
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