Ethyl bromoacetate → HCID 178472961, 화합물
반응식
[NH:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[OH:12])=[N:2]1.C([O-])([O-])=O.[K+].[K+].Br[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>CC#N.O>[NH:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[O:12][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[N:2]1참가 물질
6
실험 절차
To a solution of 2-(1H-pyrazol-3-yl) phenol (400 mg, 2.5 mmol) and K2CO3 (518 mg, 3.75 mmol) in CH3CN (10 mL) was added ethyl 2-bromoacetate (418 g, 2.5 mmol). The mixture was stirred at room temperature for 2 h, diluted with water, extracted with ethyl acetate and concentrated. The crude material was purified by column chromatography. (129 mg, yield 21%) MS (ESI+) e/z: 247.2 [M+1]+.
후처리
- extractionextracted with ethyl acetate
- concentrationconcentrated
- customThe crude material was purified by column chromatography
출처 및 근거
- ORD 기록
- ord-724bc99a721e4a4dad4dd93933c94839
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09221794B2
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