Ethyl bromoacetate → Ethyl 2-(2-(methylsulfonyl)phenoxy)acetate

HRID 1507033노트

반응식

HRID 1507033 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])(=[O:4])=[O:3].C([O-])([O-])=O.[K+].[K+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>CC#N.O>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])(=[O:3])=[O:4]

참가 물질

6

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 5989982-Methanesulfonylphenol

생성물 1

HCID 86729449Ethyl 2-(2-(methylsulfonyl)phenoxy)acetate수율 94%

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매

반응 조건

온도
80 °C

실험 절차

To a solution of 2-(methylsulfonyl)phenol (100 mg, 0.58 mmol) and K2CO3 (276 mg, 2 mmol) in CH3CN (10 mL) was added ethyl 2-bromoacetate (115.2 mg, 0.69 mmol) at 25° C. The mixture was heated at 80° C. for 4 h, diluted with water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and concentrated. The crude product was used in the next step without further purification. (140 mg, yield 94%).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. customThe crude product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-8f4369eea7ee4feda7a9a58b0b1562f3
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221794B2

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