3-Amino-1-propanol → HCID 90093058, 화합물

반응식

[CH:1]([C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=1)=O.[NH2:14][CH2:15][CH2:16][CH2:17][OH:18]>>[OH:18][CH2:17][CH2:16][CH2:15][NH:14][CH2:1][C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=1

참가 물질

반응물 2

HCID 90863-Amino-1-propanol

HCID 19600808Ethyl 2-formylpyridine-4-carboxylate

생성물 1

HCID 90093058HCID 90093058, 화합물

실험 절차

By General Procedure A from ethyl 2-formylpyridine-4-carboxylate and 3-aminopropan-1-ol. Purification by column chromatography (0-5% MeOH in DCM) gave the title compound. 1H NMR (300 MHz, CDCl3), δ ppm: 8.72 (d, 1H), 7.98 (s, 1H), 7.75 (d, 1H), 4.45 (q, 2H), 3.95 (s, 2H), 3.70 (t, 2H), 2.80 (t, 2H), 1.75 (m, 2H), 1.40 (t, 3H).

후처리

customPurification by column chromatography (0-5% MeOH in DCM)

출처 및 근거

ORD 기록: ord-8b3290da2f41410ba1bd95d95a7c11dd
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09221801B2

반응 노트

불러오는 중…