Diethyl 2-(benzo[d]thiazol-2-yl)malonate → HCID 178517545, 화합물

HRID 1507515

반응식

HRID 1507515 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([C:7](=[NH:9])[NH2:8])[CH2:3][CH2:2]1.[S:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=[C:11]1[CH:19]([C:25](OCC)=[O:26])[C:20](OCC)=[O:21]>C1(C)C=CC=CC=1>[S:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]=[C:11]1[C:19]1[C:25]([OH:26])=[N:9][C:7]([CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:8][C:20]=1[OH:21]

참가 물질

4

반응물 2

HCID 3922432Diethyl 2-(benzo[d]thiazol-2-yl)malonateHCID 11355674HCID 11355674, 화합물

생성물 1

HCID 178517545HCID 178517545, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of oxane-4-carboximidamide (160 mg, 1.25 mmol, 1.00 equiv), and 1,3-diethyl 2-(1,3-benzothiazol-2-yl)propanedioate (366 mg, 1.25 mmol, 1.00 equiv) in Toluene (3 mL) was heated for 3 h at 110° C. in an oil bath. After concentrated under reducing pressure, 460 mg (crude) of the title compound was obtained as a white solid, which was used directly for next step without further purification. MS m/z [M+H]+ (ESI): 330.

후처리

  1. concentrationAfter concentrated
  2. customwas obtained as a white solid, which
  3. customwas used directly for next step without further purification

출처 및 근거

ORD 기록
ord-00036d3f50b740748774fd20f425435f
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221809B2

연결된 노트

불러오는 중…