HCID 178506118, 화합물 → 7-(Trifluoromethyl)benzo[d]thiazole

HRID 1507521노트

반응식

HRID 1507521 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[C:11]2[S:10][C:9](S)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1>C(O)(=O)C.[Fe]>[F:14][C:2]([F:1])([F:13])[C:3]1[C:11]2[S:10][CH:9]=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 1

HCID 178506118HCID 178506118, 화합물

생성물 1

HCID 233232027-(Trifluoromethyl)benzo[d]thiazole수율 80.7%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

실험 절차

Following the same procedure as in step 2 of Example 337 using 7-(trifluoromethyl)-1,3-benzothiazole-2-thiol (300 mg, 1.28 mmol, 1.00 equiv) and iron powder (710 mg, 10.00 equiv) in acetic acid (12.0 mL). 210 mg of the title compound was obtained as a crude product as a gray-white solid, which was used directly for next step without further purification.

출처 및 근거

ORD 기록
ord-e161881f33114723b24e920a8bf67fae
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221809B2

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