3-Chloropyridine-4-carboxylic acid → 3-Chloro-N-(1-cyclopropyl-3,3-dimethyl-2-oxoindolin-6-yl)isonicotinamide

반응식

[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:26])([CH3:25])[C:17](=[O:24])[N:18]2[CH:21]2[CH2:23][CH2:22]2)=[CH:14][CH:13]=1>>[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:26])([CH3:25])[C:17](=[O:24])[N:18]2[CH:21]2[CH2:22][CH2:23]2)=[CH:14][CH:13]=1)=[O:6]

참가 물질

반응물 2

HCID 27358163-Chloropyridine-4-carboxylic acid

HCID 1184151856-Amino-1-cyclopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one

생성물 1

HCID 734258273-Chloro-N-(1-cyclopropyl-3,3-dimethyl-2-oxoindolin-6-yl)isonicotinamide

실험 절차

Prepared in analogy to example 26 from 3-chloroisonicotinic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one (example 14c). The title compound was obtained as white foam.

출처 및 근거

ORD 기록: ord-a828bdbf0e664e8597a93931f2b5849f
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09221816B2

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