3-Chloropyridine-4-carboxylic acid → 3-Chloro-N-(1-ethyl-3,3-dimethyl-2-oxoindolin-6-yl)isonicotinamide

반응식

[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:25])([CH3:24])[C:17](=[O:23])[N:18]2[CH2:21][CH3:22])=[CH:14][CH:13]=1>>[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:24])([CH3:25])[C:17](=[O:23])[N:18]2[CH2:21][CH3:22])=[CH:14][CH:13]=1)=[O:6]

참가 물질

반응물 2

HCID 27358163-Chloropyridine-4-carboxylic acid

HCID 69068988HCID 69068988, 화합물2회

생성물 1

HCID 734259473-Chloro-N-(1-ethyl-3,3-dimethyl-2-oxoindolin-6-yl)isonicotinamide

실험 절차

Prepared in analogy to example 26 from 3-chloroisonicotinic acid and 6-amino-1-ethyl-3,3-dimethylindolin-2-one (G. Georges et al., US2006/142247 A1). The title compound was obtained as white solid.

출처 및 근거

ORD 기록: ord-faa9b535ab434aa99ad0492f80cd87f2
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09221816B2

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