참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Ethyl bromoacetate | HCID 7748 | — |
| 반응물 | 4-Fluoroaniline | HCID 9731 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 생성물 | ethyl N-(4-fluorophenyl)glycine | HCID 61998283 | — |
반응 단계
Using the procedure described in WO 9857937 A2, to a solution of 13.56 g (122 mmole) p-fluoroaniline in DMF (100 mL) under nitrogen was added 23.5 g (141 mmol) of ethyl bromoacetate and 14.95 g (141 mmol) anhydrous sodium carbonate. The mixture was heated to 70° C. for 16 h and then cooled to room temperature. Water was added (500 mL) and the mixture stirred vigorously until a precipitate formed. The solid was filtered, washed with 100 mL water and dried to afford ethyl N-(4-fluorophenyl)glycine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09221805B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_12 |
|---|
| ORD ID | ord-e85fbe1affef462ab50755d2d5a46483 |
|---|
| 출처 메모 | uspto-grants-2015_12 |
|---|
