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3-Chloro-4-fluoroaniline → N-(3-chloro-4-fluorophenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine

HRID 1507867
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HRID 1507867 반응식
Cl[C:2]1[C:3]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[Cl:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][C:25]=1[F:26])[NH2:22]>ClCCCl.CC(O)(C)C>[Cl:18][C:19]1[CH:20]=[C:21]([NH:22][C:2]2[C:3]3[CH:10]=[C:9]([C:11]4[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=4)[S:8][C:4]=3[N:5]=[CH:6][N:7]=2)[CH:23]=[CH:24][C:25]=1[F:26]
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참가 물질

4

반응물 2

HCID 97083-Chloro-4-fluoroanilineHCID 866624414-Chloro-6-(4-fluorophenyl)thieno[2,3-d]pyrimidine

생성물 1

HCID 56941891N-(3-chloro-4-fluorophenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine수율 50%

시약·촉매·용매 1

HCID 21868497Tert-butyl alcohol 1,2-dichloroethane용매

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온도
90 °C

실험 절차

To a solution of 4-chloro-6-(4-fluorophenyl)thieno[2,3-d]pyrimidine (40 mg, 0.15 mmol) in 1,2-dichloroethane/t-BuOH (1:1, 1 ml) was added 3-chloro-4-fluoroaniline (22 mg, 0.15 mmol). The mixture was heated at 90° C. for 2 days. After cooling down to room temperature, the solvents were removed under reduced pressure. The crude residue was purified by silica gel chromatography (CH2Cl2/MeOH 100:1) to yield the title compound as a white solid (28 mg, 50%).

후처리

  1. temperatureAfter cooling down to room temperature
  2. customthe solvents were removed under reduced pressure
  3. customThe crude residue was purified by silica gel chromatography (CH2Cl2/MeOH 100:1)

출처 및 근거

ORD 기록
ord-5510c71cc19244ccb4d87f14f34e8de5
출처 데이터셋
uspto-grants-2015_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09221822B2

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