Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 15079생성일: 2026년 10월 23일
Dimethylformamide → 4-[(5-Chloro-2-pyridinyl)methoxy]-1-(4-{2-[isopropyl(methyl)amino]ethoxy}-phenyl)-1H-pyridin-2-one
https://huagongshe.com/ko/reaction/15079
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | N-Methylisopropylamine | HCID 78485 | — |
| 반응물 | 1-[4-(2-bromoethoxy)phenyl]-4-[(5-chloro-2-pyridinyl)-methoxy]-1H-pyridin-2-one | HCID 68431096 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-[(5-Chloro-2-pyridinyl)methoxy]-1-(4-{2-[isopropyl(methyl)amino]ethoxy}-phenyl)-1H-pyridin-2-one | HCID 11640508 | 99% |
반응 단계
A mixture of 1-[4-(2-bromoethoxy)phenyl]-4-[(5-chloro-2-pyridinyl)methoxy]-1H-pyridin-2-one (1.1 g, 2.6 mmols, Step (1) of Example 109), isopropyl(methyl)amine (0.811 mL, 7.8 mmols) and DMF (2.6 mL) was stirred at 60° C. for 2 days. Water was added to the reaction liquid and filtered. So obtained crude title compound was purified on silica gel column chromatography (KP-Sil FLASH 25+M, chloroform:methanol=1:0→5:1) to provide the title compound (1.1 g, 99%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07732456B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-931df4c3aadd420e897071d9b62616a7 |
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| 출처 메모 | uspto-grants-2010_06 |
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