참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 4-Nitrophenethyl bromide | HCID 79266 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 4-[2-(4-Nitrophenyl)ethyl]morpholine | HCID 2797473 | — |
반응 단계
A mixture of 1-(2-bromo-ethyl)-4-nitro-benzene (0.740 g, 3.22 mmol), morpholine (0.840 mL, 9.65 mmol), and sodium iodide (0.480 g, 3.22 mmol) in N,N-dimethylacetamide (3 mL) was heated at 80° C. for 10 min. The mixture was diluted with 30 mL EtOAc and washed with H2O (2×30 mL) and brine (30 mL) and dried over Na2SO4 to give the title compound as a yellow oil of sufficient purity to use in the next step. Mass spectrum (ESI, m/z): Calcd. for C12H16N2O3, 237.1 (M+H). found 237.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09221797B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_12 |
|---|
| ORD ID | ord-5bff33b4e614485fac529b712ed10e34 |
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| 출처 메모 | uspto-grants-2015_12 |
|---|
