Triethylamine → 3-Bromo-2-chloro-6-fluorobenzonitrile

HRID 1508171노트

반응식

HRID 1508171 반응식
[Br:1][C:2]1[C:3]([Cl:12])=[C:4]([C:8]([F:11])=[CH:9][CH:10]=1)[C:5]([NH2:7])=O.CCN(CC)CC.FC(F)(F)S(OS(C(F)(F)F)(=O)=O)(=O)=O>C(Cl)Cl>[Br:1][C:2]1[C:3]([Cl:12])=[C:4]([C:8]([F:11])=[CH:9][CH:10]=1)[C:5]#[N:7]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 712395033-Bromo-2-chloro-6-fluorobenzamide

생성물 1

HCID 712393913-Bromo-2-chloro-6-fluorobenzonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-bromo-2-chloro-6-fluorobenzamide (3.56 mmol) in 50 mL DCM were added 1.5 mL Et3N followed by trifluoromethanesulfonic acid anhydride (7.11 mmol) at 0° C. The ice bath was removed and the reaction mixture was stirred at RT. After 30 min, water was added and the mixture was extracted with DCM (3×). The combined organic layers were dried over MgSO4 and concentrated in vacuo to obtain the desired compound as brown solid.

후처리

  1. customThe ice bath was removed
  2. additionwater was added
  3. extractionthe mixture was extracted with DCM (3×)
  4. dry with materialThe combined organic layers were dried over MgSO4
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0417eee7762a4333be31dc3b00dc285b
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221832B2

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