Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → (3S)-1-benzyl-3-acetoxypyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | (S)-(-)-1-Benzyl-3-pyrrolidinol | HCID 2733875 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (3S)-1-benzyl-3-acetoxypyrrolidine | HCID 15623663 | 90% |
반응 단계
Triethylamine (1.3 mL, 9.30 mmols) and acetyl chloride (0.6 mL, 8.46) were added to THF (20 mL) solution of (3S)-1-benzyl-3-hydroxypyrrolidine (1.5 g, 8.46 mmols) by the order stated, under cooling with ice, and stirred at the same temperature for an hour. Ethyl acetate was added to the reaction liquid which then was washed with water and saturated brine, and dried over anhydrous sodium sulfate. Concentrating the reaction liquid under reduced pressure, the residue was purified on silica gel column chromatography (KP—NH, ethyl acetate:hexane=1:20) to provide the title compound (1.68 g, 90%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732456B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-08c55e9d266e442688fef7b33c0e6450 |
| 출처 메모 | uspto-grants-2010_06 |