Sodium Methoxide → HCID 86069111, 화합물

HRID 1508244노트

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HRID 1508244 반응식
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[C:10](Br)=[CH:9][CH:8]=[N:7][C:6]=1[Cl:12])[CH3:2].[CH3:14][O-:15].[Na+]>CO.CCOC(C)=O>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[C:10]([O:15][CH3:14])=[CH:9][CH:8]=[N:7][C:6]=1[Cl:12])[CH3:2]

참가 물질

5

반응물 2

HCID 10942334Sodium MethoxideHCID 84819634Ethyl 4-bromo-2-chloronicotinate

생성물 1

HCID 86069111HCID 86069111, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

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온도
40 °C

실험 절차

To a solution of 4-bromo-2-chloronicotinic acid ethyl ester (5.06 mmol) in 15 mL MeOH was added 1.0 mL of a solution of NaOMe (30% in MeOH). The reaction mixture was stirred at 40° C. for 4 h, cooled to RT, diluted with EtOAc and then quenched with sat. aq. NH4Cl solution. The organic layers was dried over MgSO4 and concentrated in vacuo to give the desired compound as brown oil;

후처리

  1. temperaturecooled to RT
  2. customquenched with sat. aq. NH4Cl solution
  3. dry with materialThe organic layers was dried over MgSO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f11930c306814e92a4e8cfe1c8246883
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221832B2

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