Trimethylsilyldiazomethane → (5-(Methoxycarbonyl)furan-2-YL)boronic acid
반응식
[OH:1][B:2]([OH:11])[C:3]1[O:7][C:6]([C:8]([OH:10])=[O:9])=[CH:5][CH:4]=1.[CH3:12][Si](C=[N+]=[N-])(C)C>C(Cl)Cl.CO>[CH3:12][O:9][C:8]([C:6]1[O:7][C:3]([B:2]([OH:1])[OH:11])=[CH:4][CH:5]=1)=[O:10]참가 물질
5
실험 절차
5-(Dihydroxyboryl)-2-furoic acid (200 mg, 1.283 mmol) was dissolved in CH2Cl2 (5 mL) and MeOH (0.556 mL). Trimethylsilyldiazomethane (1.283 mL, 2.57 mmol) was added dropwise. After 45 min, the reaction was quenched with AcOH dropwise until the yellow color disappeared. The reaction was concentrated in vacuo to give [5-(methoxycarbonyl)-2-furyl]boronic acid. 1H NMR (500 MHz, CD3OD): δ 7.20 (d, J=3.5 Hz, 1H); 7.05 (d, J=3.6 Hz, 1H); 3.87 (s, 3H).
후처리
- customthe reaction was quenched with AcOH dropwise until the yellow color
- concentrationThe reaction was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-1b41a39b4e1449f395f6ec3450c06de5
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09221834B2
반응 노트
불러오는 중…