Cyanamide → HCID 178512257, 화합물

HRID 1508700노트

반응식

HRID 1508700 반응식
[Cl:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[CH:4][CH:3]=1.O(C)[Na].[NH2:12][C:13]#N.[NH4+:15].[Cl-]>CO>[Cl:1][C:2]1[S:6][C:5]([C:7](=[NH:15])[NH:8][C:13]#[N:12])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 9864CyanamideHCID 25517Ammonium ChlorideHCID 122032655-Chloro-2-thiophenecarbonitrileHCID 178418582HCID 178418582, 화합물

생성물 1

HCID 178512257HCID 178512257, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 5-chlorothiophene-2-carbonitrile 1 in MeOH was added NaOCH3. The reaction mixture was stirred at room temperature for 4 h and then NH2CN was added. The reaction was allowed stir for overnight under N2. The mixture was then poured into NH4Cl (aq) and the precipitate collected and washed with water. The dried sample was confirmed as desired product 5-chloro-N-cyanothiophene-2-carboximidamide 2.

후처리

  1. stirringThe reaction was allowed stir for overnight under N2
  2. customthe precipitate collected
  3. washwashed with water

출처 및 근거

ORD 기록
ord-2b2e2c1a069d4abc9fd26b833e6bcf8c
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221843B2

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